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US 2026/0028591 A1Published application
Enhanced differentiation of pancreatic islet cells
AssigneeVertex Pharmaceuticals Incorporated
InventorsChunhui Xie, George Harb, Elizabeth Ryu, Nicholas Teceno, Christopher Farrar, Bryce W. Carey
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Abstract
Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
Claims20
A composition comprising in vitro differentiated cells;
- wherein at least 50% of the cells in the composition are NKX6.1-positive, ISL1-positive cells;
- wherein at least 80% of the cells in the composition are ISL1-positive cells;
- and wherein 15-30% of the cells in the composition are NKX6.1-negative, ISL1-positive cells.
Dependencies are inferred from the claim text.