Retention system

A disposable and pre-sterilized bioprocess system for processing a biological material contained in a liquid, comprising:

• a) at least one first housing for conveying the biological material containing liquid, wherein the at least one first housing has at least one stationary wall surrounding at least one chamber comprising a pumping element for conveying the biological material containing liquid, wherein a Programmable Logic Control System (PLC) for regulation purposes receives information for either velocity, or revolution, or volume or pressure or time of said liquid passing the pumping element said pumping element regulation based on a program stored in a memory of the PLC, wherein the at least one first housing for conveying the biological material containing liquid is selected from the group consisting of:
• (i) a centrifugal pump, wherein the pumping element is a rotating element,
• and
• (ii) a peristaltic pump, wherein the pumping element is a tube situated between at least two moving elements and a stationary wall,
• b) at least one second housing comprising at least one permeable membrane filter having a non-filtered liquid and a filtered liquid side,
• the at least one second housing having at least one first housing port being a non-filtered liquid entrance and/or exit port,
• the at least one second housing having at least one second housing port being a non-filtered liquid exit and/or entrance port,
• the at least one second housing having at least one third housing port being a concentrated liquid permeate exit port, and
• wherein the at least one first housing port is in liquid communication with said non-filtered liquid side of said at least one second housing and said at least one second housing port conveys harvested and filtered liquid that has passed through said at least one permeable membrane filter of said at least one second housing.