Polymeric tandem dyes with spacing linker groups
AssigneeSony Group Corporation
InventorsHesham SHERIF, Eriko MATSUI
Life of this patent
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Abstract
Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): (I) or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L1a, L1b, L2, L3, L4, L5, L6, L7, M1, M2, m, n, q, and w are as defined herein. Methods associated with preparation and use of such compounds are also provided.
Claims35
A polymeric dye comprising:
- i) two or more FRET donors;
- ii) at least one FRET acceptor, wherein the at least one FRET acceptor is independently a moiety comprising four or more aryl or heteroaryl rings, or combinations thereof, provided that a number of the FRET donors is greater than a number of FRET acceptor;
- and
- iii) at least one negatively charged group,
- wherein:
- A) a distance between each of the two or more FRET donors is 4.0 nm or more in space;
- B) a distance between the two or more FRET donors and the at least one FRET acceptor is up to 3.0 nm in space;
- C) each of the two or more FRET donors are joined via a linker comprising the at least one negatively charged group;
- and
- D) the two or more FRET donors and the at least one FRET acceptor are joined via a linker comprising the at least one negatively charged group.
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A polymeric dye having one of the following structural orientations:
- wherein:
- A represents a FRET acceptor, wherein the A is placed at a center of a sphere;
- D represents a FRET donor, wherein each D is placed on a surface of the sphere, separated from another D by a first distance, and separated from the A by a second distance;
- the first distance is 4.0 nm or more in space;
- the second distance is up to 3.0 nm in space;
- the sphere is defined by a radius between the A and the D;
- each FRET donor is joined via a linker comprising at least one negatively charged group;
- and
- each FRET donor and the FRET acceptor are joined via a linker comprising the at least one negatively charged group.
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Dependencies are inferred from the claim text.