High-durability glycosaminoglycan gels and methods of making the same
AssigneeGalderma Holding SA
InventorsLina KANDELIN, Kristoffer BERGMAN
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Abstract
Disclosed are durable polysaccharide compositions comprising GAGs covalently crosslinked with a carbohydrate crosslinker, and methods of making the same. GAG hydrogels according to the present disclosure have a molecular weight of at least 1.5 MDa, crosslinked by a crosslinker forming amide bonds with the GAG backbone and an elastic modulus (G′) of less than or equal to 200 Pa. Further described are methods of using the durable polysaccharide compositions for treating skin (e.g., in reparative or plastic surgery, esthetic dermatology, facial contouring, body contouring, or gingival augmentation).
Claims20
A method of preparing a hydrogel comprising crosslinked glycosaminoglycan (GAG) molecules, the method comprising:
- crosslinking a GAG having a molecular weight of at least 1.5 MDa with a crosslinker to obtain a GAG hydrogel crosslinked by amide bonds, wherein:
- the concentration of GAG is less than 2 wt. % during the crosslinking;
- the molar ratio of the crosslinker to the GAG is greater than or equal to 1.5 mol % per GAG disaccharide during the crosslinking;
- and
- the GAG hydrogel has an elastic modulus (G′) of less than or equal to 200 Pa.
A GAG hydrogel, comprising:
- hyaluronic acid (HA) molecules crosslinked by diaminotrehalose (DATH) through amide bonds between the HA molecules and the DATH, wherein:
- the HA has a weight average molecular weight of greater than or equal to 2 MDa;
- the molar ratio of the crosslinker to the HA is greater than or equal to 1.5 mol % per GAG disaccharide;
- and
- the GAG hydrogel has an elastic modulus (G′) of less than or equal to 200 Pa.
Dependencies are inferred from the claim text.