US 2026/0028443 A1 · POLYMER MEDICAMENT FOR TREATING HYPERKALEMIA AND PREPARATION METHOD THEREOF

Abstract

Provided are a polymer medicament for treating hyperkalemia, and a preparation method thereof. Specifically, a polymer is provided, and the polymer includes repeating units obtained by polymerizing a monomer and a crosslinking agent. A molar ratio of the monomer to the crosslinking reagent ranges from 1:0.02 to 1:0.20. The monomer includes an acidic group and a pKa-reducing group next to the acidic group. The acidic group is selected from the group consisting of sulfonic acid group (—SO3−), sulfuric acid group (—OSO3−), carboxylic group (—CO2−), phosphonic acid group (—OPO32−), phosphate group (—OPO32−), and sulfamic acid group (—NHSO3−). The pKa-reducing group is selected from the group consisting of nitro, cyano, carbonyl, trifluoromethyl, and halogen atoms. The crosslinking agent has three or four reaction sites. The polymer can be used to treat hyperkalemia.

Claims11

Dependent claims

A polymer, having a structure represented by formula (I) or being a salt of the structure represented by formula (I):

wherein, R1 is
when R1 contains three binding sites, R2 is not present;
and when R1 contains four binding sites, R2 is connected to one of the four binding sites of R1 and R2 is
m ranges from 0.80 to 0.98, n ranges from 0.02 to 0.20, and m+n=1;
n1, n2, n3, n4, and n5 are each independently selected from 0, 1, 2, 3, 4, 5, 6, or 7;
X1, X2, X3, X4, X5, and X6 are each independently a carbon atom or a nitrogen atom;
m1 is 0 or 1;
and
* represents a binding site.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

19/342,711Filed 29 Sep 2025

Priority

16 Mar 2022

Published

29 Jan 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

C08G 8/14
Of formaldehyde, e.g. of formaldehyde formed in situ: with halogenated phenols
A61K 31/765
Synthetic polymeric materials: polymers containing oxygen
A61K 31/78
Polymers containing oxygen: of acrylic acid or derivatives thereof
A61K 31/787
Polymers containing nitrogen: containing heterocyclic rings having nitrogen as a ring hetero atom

Polymer medicament for treating hyperkalemia and preparation method thereof

Life of this patent

Polymer medicament for treating hyperkalemia and preparation method thereof

Life of this patent

Abstract

Claims11