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US 2026/0028375 A1Published application
Polypeptides self-assembling into nanoparticles
AssigneeETH Zurich
InventorsThomas George Watt EDWARDSON, Donald HILVERT
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Abstract
The present invention relates to polypeptides self-assembling into nanoparticles. In particular, the invention relates to a polypeptide comprising an amino acid sequence I (SEQ ID NO: 1), a nucleic acid sequence encoding said polypeptide, a nanoparticle comprising at least one polypeptide of the invention, a complex comprising said nanoparticle and one or more cargo molecules, and a method for transfecting a cell with said complex.
Claims20
A polypeptide comprising an amino acid sequence I consisting of:
- (SEQ ID NO:
- 1)
- MX13QAIGILELX1SIAAGMELGDAMLKSAX14VX15LLVSKTISX2GK
- FLLMLGGDIX8AIX9X12AIX10TGTX11QAGX3LLVDSLVLAX16IHP
- SVLPAIX17GX18NX19VX20X7X21QAVGIVETX4SVAACISAADX22
- AVX23GSX24VTLVRVHMAX5GIGGKCYMVVAGDVSDVALAVTVASSSA
- GAYGX6LVYASLIPX25PHX26AMWX27QMVX28GX29E,
- wherein any of X1 to X29 are independently of each other an amino acid, provided that at least 3 of X1 to X6 are independently of each other a positively charged amino acid, and wherein optionally up to 5 amino acids in positions other than denoted by X1 to X29 in SEQ ID NO:
- 1 are exchanged by any amino acid.
6 more elements
Dependencies are inferred from the claim text.