Macrocyclic imidazo [1,2-b] pyridazine derivative, preparation method therefor, and use thereof

A macrocyclic imidazo [1,2-b] pyridazine compound represented by formula I, or an isotopically labeled compound, an optical isomer, a geometric isomer, a tautomer, an isomers mixture, a pharmaceutically acceptable salt, a prodrug, or a metabolite thereof,

• wherein,
• W1, W2, W3, W4 and W5 are each independently selected from carbon or nitrogen, and at least one of W1, W2, W3, W4 and W5 is nitrogen;
• R1, R2 and R3 are each independently selected from hydrogen, deuterium, halogen, cyano, hydroxyl, amino, substituted or unsubstituted saturated or unsaturated C1-C6 alkyl, substituted or unsubstituted saturated or unsaturated C3-C6 cycloalkyl, substituted or unsubstituted saturated or unsaturated C1-C6 alkoxy, substituted or unsubstituted saturated or unsaturated C3-C6 cycloalkoxy, or R1 and R2 together with the N and C atoms to which they are connected form a substituted or unsubstituted 4- to 10-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O and S, or a substituted or unsubstituted 5- to 14-membered heteroaryl containing 1 to 3 heteroatoms selected from N, O and S, or R2 and R3 together with the C atom to which they are connected form a substituted or unsubstituted saturated or unsaturated C3-C6 cycloalkyl;
• wherein the “substituted” refers to selectively having 1 to 4 substituents selected from deuterium, hydroxyl, halogen, cyano, sulfonyl, amino, C1-C4 alkyl, C3-C6 cycloalkyl, C1-C4 alkoxy and C3-C6 cycloalkoxy;
• R4 is selected from hydrogen, deuterium, halogen, cyano, hydroxyl, amino, saturated or unsaturated C1-C6 alkyl, saturated or unsaturated C3-C6 cycloalkyl, saturated or unsaturated C1-C6 alkoxy, and saturated or unsaturated C3-C6 cycloalkoxy;
• R5 is selected from hydrogen, deuterium, halogen, cyano, hydroxyl, amino, saturated or unsaturated C1-C6 alkyl, saturated or unsaturated C3-C6 cycloalkyl, substituted or unsaturated C1-C6 alkoxy, and saturated or unsaturated C3-C6 cycloalkoxy, or R5 is absent;
• L is selected from —O—, —NH—, substituted or unsubstituted branched or straight chain C1-C6 alkylene, substituted or unsubstituted branched or straight chain C1-C6 alkyleneoxy, substituted or unsubstituted saturated or unsaturated C3-C6 cycloalkylene, substituted or unsubstituted saturated or unsaturated C3-C6 cycloalkyleneoxy, substituted or unsubstituted branched or straight chain C1-C6 alkylenethio, substituted or unsubstituted saturated or unsaturated 3 to 6-membered oxacycloalkylene, substituted or unsubstituted saturated or unsaturated 3 to 6-membered azacycloalkylene, substituted or unsubstituted saturated or unsaturated 3 to 6-membered thiacycloalkylene, substituted or unsubstituted saturated or unsaturated 3- to 6-membered oxacycloalkyleneoxy, substituted or unsubstituted saturated or unsaturated 3- to 6-membered azacycloalkyleneoxy, substituted or unsubstituted saturated or unsaturated 3- to 6-membered thiacycloalkyleneoxy;
• wherein the “substituted” refers to selectively having 1 to 4 substituents selected from deuterium, halogen, cyano, hydroxyl, carboxyl, carbonyl, sulfonyl, amino, C1-C4 alkyl, C1-C4 hydroxyalkyl, C3-C6 cycloalkyl, C1-C4 alkoxy, C3-C6 cycloalkoxy, 4 to 8-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O and S, and 5 to 10 membered heteroaryl containing 1 to 3 heteroatoms selected from N, O and S.