N-(3-(benzo[b]thiophene-2-carboxamido)-phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide derivatives and related compounds as lactate/atp production inhibitors for the treatment of cancer

A compound of formula (I)

• or an enantiomer, diastereomer, N-oxide, solvate or pharmaceutically acceptable salt thereof, wherein
• K is O, S or C(R5)2;
• L is O, S or C(R5)2;
• n is 0, 1, 2, 3 or 4;
• p is 1 or 2;
• q is independently from each other 0, 1 or 2;
• r is 1 or 2;
• A is C1-6-alkyl, halogen, CN, halo-C1-6-alkyl, C3-6-cycloalkyl, halo-C3-6-cycloalkyl, OH, —OC1-6-alkyl or O-halo-C1-6-alkyl;
• X is S, O, NR6, N or CR7;
• Y is S, O, NR6, N or CR7;
• Z is C or N;
• D represents a 6-membered aryl or 5- to 6-membered heteroaryl containing 1 to 4 heteroatoms independently selected from O, N and S;
• R1 is F, C1-3-alkyl or spirocyclic fused C3-6-cycloalkyl;
• R2 is independently halogen or C1-6-alkyl;
• R3 is hydrogen, halogen, C1-6-alkyl, halo-C1-6-alkyl, C3-6-cycloalkyl, halo-C3-6-cycloalkyl, —OC1-6-alkyl or O-halo-C1-6-alkyl;
• R4 is hydrogen, halogen or V1-V2-V3-V4-V5
• wherein
• V1 is absent, a bond or C1-6-alkylene;
• V2 is absent, a bond or O, S, S(O)x, S(O)(═NRa), S(O)2NRa, NRa, NRaC(O) or C(O)NRa;
• V3 is absent, a bond or C1-6-alkylene;
• wherein C1-6-alkylene in V1 or V3 is unsubstituted or substituted with 1 to 4 substituents independently selected from the group consisting of OH, C1-6-alkyl, C1-6-haloalkyl, halogen and oxo,
• or
• wherein two C1-6-alkyl groups on the C1-6-alkylene in V1 or V3, together with the carbon atom to which they are attached, form a C3-6-cycloalkyl group;
• V4 is absent, a bond or O, S, S(O)x, S(O)(═NRa), S(O)2NRa, NRa, NRaC(O) or C(O)NRa;
• V5 is hydrogen, halogen, OH, CN, CO2H, CO2-C1-6-alkyl, N(Ra)2, C1-6-alkyl, C3-8-cycloalkyl, 4- to 8-membered mono or bicyclic heterocycloalkyl containing 1, 2 or 3 heteroatoms independently selected from the group consisting of O, S and N, phenyl or 5- to 6-membered heteroaryl containing 1, 2 or 3 heteroatoms independently selected from the group consisting of O, S and N,
• wherein alkyl, cycloalkyl, heterocycloalkyl, phenyl or heteroaryl are unsubstituted or substituted with 1 to 4 substituents RV5 independently selected from the group consisting of CN, CO2H, CO2—C1-6-alkyl, N(Ra)2, OH, C1-6-alkyl, O-C1-6-alkyl, C(O)-C1-6-alkyl, C1-6-haloalkyl, halogen, oxo, spirocyclicly fused C3-6-cycloalkyl and spirocyclicly fused 3-7 membered heterocycloalkyl containing 1 heteroatom selected from the group consisting of O, S and N;
• R5 is hydrogen, F, C1-3-alkyl or spirocyclic fused C3-6-cycloalkyl;
• R6 is hydrogen or C1-6-alkyl;
• R7 is hydrogen, halogen or C1-6-alkyl;
• Ra is hydrogen or C1-3-alkyl;
• and
• x is 1 or 2.