Hydrogel composition for use in the treatment of articular disorders
AssigneesUniversite De Lille, Institut National de la Sante et de la Recherche Medicale, Centre Hospitalier Universitaire De Lille, Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement, Centre National de la Recherche Scientifique (CNRS), Centrale Lille Institut
InventorsNicolas BLANCHEMAIN, Feng CHAI, Romain NICOT, Bernard MARTEL, Maria José GARCIA FERNANDEZ, Nicolas TABARY, Henry CHIJCHEAPAZA-FLORES
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Abstract
The present disclosure relates to a hydrogel composition based on anionic cyclodextrin polymers and chitosan for use in the treatment of articular disorders. In particular, the hydrogel combines a pharmacological action, in particular an analgesic action, with a visco-supplementation (a lubricating effect).
Claims10
Method for treating articular disorders, comprising administering to an individual in need thereof a hydrogel composition comprising:
- (a) a hydrogel made of a polymer network comprising:
- (i) chitosan;
- (ii) anionic cyclodextrin polymers,
- the anionic cyclodextrin polymers being water soluble anionic cyclodextrin polymers or a mixture of water soluble anionic cyclodextrin polymers and water insoluble anionic cyclodextrin polymers (CDPi),
- wherein the ratio of the weight of water soluble anionic cyclodextrin polymers to the weight of water insoluble anionic cyclodextrin polymers is about 1:1;
- wherein the ratio of the weight of the chitosan to the total weight of the anionic cyclodextrin polymers is about 2:1;
- and
- (b) optionally a pharmacological agent incorporated in the polymer network.
A method for preparing a hydrogel composition comprising:
- (a) a hydrogel made of a polymer network comprising:
- (i) chitosan;
- (ii) anionic cyclodextrin polymers,
- the anionic cyclodextrin polymers being water soluble anionic cyclodextrin polymers or a mixture of water soluble anionic cyclodextrin polymers and water insoluble anionic cyclodextrin polymers (CDPi),
- wherein the ratio of the weight of water soluble anionic cyclodextrin polymers to the weight of water insoluble anionic cyclodextrin polymers is about 1:1;
- wherein the ratio of the weight of the chitosan to the total weight of the anionic cyclodextrin polymers is about 2:1;
- and
- (b) optionally a pharmacological agent incorporated in the polymer network comprising the following steps:
- (i) providing powders of water soluble anionic cyclodextrin polymer, water insoluble anionic cyclodextrin polymer powder when applicable and chitosan;
- (ii) adding by wet granulation a pharmacological agent to the water soluble anionic cyclodextrin polymer powder or to the mixture of water soluble and water insoluble anionic cyclodextrin polymer powders;
- (iii) dry mixing the powder obtained in step (ii) with chitosan powder in order to form a mixture of powders;
- (iv) optionally sieving, or co-milling and sieving, the mixture of powders obtained in step (iii);
- (v) suspending the mixture of powders obtained in step (iv) in an aqueous medium having a pH that enables the anionic cyclodextrin polymer(s) to be dissolved without dissolving the chitosan;
- (vi) acidifying the suspension obtained from step (v) in order to form the hydrogel composition.
Dependencies are inferred from the claim text.