Targeted Pyrrolobenzodiazapine Conjugates

A compound of Formula B(i) or B(ii):

• or a pharmaceutically acceptable salt, tautomer, solvate, or stereoisomer thereof, wherein:
• each of ring A and ring B is, independently, one of the following formulas:
• indicates the point of attachment to Linker or Ab Linker;
• Linker is —(CH2)r—, —(CH2)p—X—(CH2)q—, or —(CH2)p—CH═CH—(CH2)q—;
• X is NR6, NHC(═O), C(═O)NH, O, SO2, a substituted or unsubstituted aryl ring, substituted or unsubstituted heteroaryl ring, substituted or unsubstituted heterocyclic ring, or substituted or unsubstituted cyclic ring;
• ring C is a cyclopropyl ring or a cyclobutyl ring;
• each of the dotted bonds between —C(R1)— and —N(R2)— is, independently, a single bond or a double bond;
• when the dotted bond is a single bond, each R1 is, independently, H or OH, and each R2 is H;
• when the dotted bond is a double bond, each R1 is, independently, H, and each R2 is absent;
• each of R3 and R4 is, independently, H, NH2, NaRb, OH, C1-4 alkyl, C1-4 alkoxyl, or aryl;
• Ra and Rb are each independently H or C1-4 alkyl;
• R5 is H, C1-4 alkyl, C1-4 alkoxyl, or aryl;
• R6 is H or C1-4 alkyl;
• each of m, n, and o is, independently, 1 or 2;
• each of r, p, and q, is, independently, an integer from 1 to 8;
• the sum of p and q is an integer from 1 to 8;
• and
• Ab Linker is a compound able to join ring A or ring B to a binding agent.

A conjugate of Formula A(i) or A(ii):

• or a pharmaceutically acceptable salt, tautomer, solvate, or stereoisomer thereof, wherein:
• each of ring A and ring B is, independently, one of the following formulas:
• indicates the point of attachment to Linker or Ab Linker;
• Linker is —(CH2)r—, —(CH2)p—X—(CH2)q—, or —(CH2)p—CH═CH—(CH2)q—;
• X is NR6, NHC(═O), C(═O)NH, O, SO2, a substituted or unsubstituted aryl ring, substituted or unsubstituted heteroaryl ring, substituted or unsubstituted heterocyclic ring, or substituted or unsubstituted cyclic ring;
• ring C is a cyclopropyl ring or a cyclobutyl ring;
• each of the dotted bonds between —C(R1)— and —N(R2)— is, independently, a single bond or a double bond;
• when the dotted bond is a single bond, each R1 is, independently, H or OH, and each R2 is H;
• when the dotted bond is a double bond, each R1 is, independently, H, and each R2 is absent;
• each of R3 and R4 is, independently, H, NH2, NRaRb, OH, C1-4 alkyl, C1-4 alkoxyl, or aryl;
• Ra and Rb are each independently H or C1-4 alkyl;
• R5 is H, C1-4 alkyl, C1-4 alkoxyl, or aryl;
• R6 is H or C1-4 alkyl;
• each of m, n, and o is, independently, 1 or 2;
• each of r, p, and q, is, independently, an integer from 1 to 8;
• the sum of p and q is an integer from 1 to 8;
• Ab Linker is a compound that joins Ab to ring A or ring B;
• Ab is a binding agent selected from a humanized, chimeric, or human antibody, or an antigen binding fragment thereof, and subscript x is from 1 to 15.