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AssigneeAtopic Medical, LLC
InventorsThomas J. Borody, Debra A. Peattie
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Disclosed are compositions and methods for treating, amelioriating, reversing and/or preventing (acting as a prophylaxis): a respiratory condition involving an infection or an inflammation, or any lung condition involving inflammation or infection, e.g., of a respiratory mucosa, and/or an infection or an inflammation of an underlying muscle of the respiratory tract; or, an asthma; a bronchitis; a sinusitis or rhinosinusitis; an infection of a sinus; chronic obstructive airway disease; emphysema; chronic bronchitis; pneumonia; or, a bronchiectasis. In alternative embodiments, the therapeutic combination comprises an orally administered Amphotericin B or equivalent antifungal alone, or a combination of Amphotericin B and: one antibiotic; two antibiotics; three antibiotics; or, four or more antibiotics. In alternative embodiments, these compositions and methods are dosaged and administered to children in need thereof. In alternative embodiments, compositions and methods of the invention are dosaged, formulated and dosaged as tablet, capsule, liquid, powder or aerosol preparations or formulations, or preparations or formulations for oral delivery or inhalation.
A therapeutic combination, or an orally or inhalation formulated Amphotericin B or an equivalent antifungal agent or composition,
The therapeutic combination, or the orally formulated Amphotericin B or an equivalent antifungal agent or composition, of any one of the preceding claims, wherein the at least one additional anti-fungal agent or composition is selected from the group consisting of:
The therapeutic combination, or the orally formulated Amphotericin B or an equivalent antifungal agent or composition, of any one of the preceding claims, wherein the (a) one antibiotic or antibacterial agent;
The therapeutic combination, or the orally formulated Amphotericin B or an equivalent antifungal agent or composition, of any one of the preceding claims, wherein the (a) one antibiotic or antibacterial agent;
The therapeutic combination, or the orally formulated Amphotericin B or an equivalent antifungal agent or composition, of any one of the preceding claims, wherein the (a) one antibiotic or antibacterial agent;
The therapeutic combination, or the orally formulated Amphotericin B or an equivalent antifungal agent or composition, of any one of the preceding claims, wherein the (b) two antibiotics or antibacterial agents;
The therapeutic combination, or the orally formulated Amphotericin B or an equivalent antifungal agent or composition, of any one of the preceding claims, wherein the Amphotericin B is formulated or oral administration as or in:
The therapeutic combination, or the orally formulated Amphotericin B or an equivalent antifungal agent or composition, of any one of the preceding claims, wherein the orally formulated Amphotericin B or an equivalent antifungal agent or composition is formulated for administration alone in an amount of about 250 mg per day, or about 200 to 300 mg per day, or about 300 to 500 mg per day, or about 100, 200, 300, 400 or 500 mg per day, which optionally can be formulated for administration once a day, bid, or tid.
The therapeutic combination, or the orally formulated Amphotericin B or an equivalent antifungal agent or composition, of any one of the preceding claims, wherein the orally formulated Amphotericin B is or comprises:
A method for the treatment of at least one fungal infection, or for the treatment of a co-infection by at least one fungi and at least one other infectious agent, in an individual in need thereof,
Dependencies are inferred from the claim text.