Topical Roflumilast Aerosol Foams
AssigneeArcutis Biotherapeutics, Inc.
InventorDavid W. OSBORNE
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Abstract
The present invention is directed to an aerosol foam composition comprising roflumilast, an emulsifier blend containing cetearyl alcohol, dicetyl phosphate, and ceteareth-10 phosphate and a hydrocarbon propellant. The aerosol foam composition is preferably an oil in water emulsion. The propellant is a mixture of liquefied hydrocarbon gases preferably a propane/isobutane/butane blend. The hydrocarbon propellant results in an aerosol foam which is stable, has consistent physical properties, excellent aesthetics, and no discernable degradation after long term or accelerated storage conditions.
Claims23
A method of inhibiting phosphodiesterase 4 in a patient, comprising topically applying an aerosol foam to the skin of the patient, wherein the aerosol foam comprises roflumilast, cetearyl alcohol, dicetyl phosphate, ceteareth-10 phosphate in an oil in water emulsion and a propane/isobutane/butane propellant blend, to a patient in need thereof;
- wherein said oil in water emulsion has a viscosity of 4,000-11,000 cP, wherein said propellant and oil in water emulsion are in a ratio of about 1:8 to 1:6, and wherein said aerosol foam is emitted from a container but collapses after application to the patient's skin.
Dependencies are inferred from the claim text.