Cannabinoid acid ester compositions and uses thereof
AssigneesEpm (IP), Inc., Yissum Research Development Company of the Hebrew University of Jerusalem
InventorsDror Robinson, Dan Peer, Joseph Tam, Raphael Mechoulam
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Abstract
The present disclosure provides pharmaceutical compositions including a cannabinoid acid ester compound alone or in combination with one or more additional cannabinoid compounds. In some embodiments, the cannabinoid acid ester compound is a cannabidiolic acid ester. A variety of therapeutic applications in which the cannabinoid acid ester compounds and pharmaceutical compositions find use are also provided, including combination therapies using cannabinoid acid ester compounds and one or more additional therapeutic agents.
Claims20
A method of treating a disease or disorder selected from the group consisting of:
- (i) a gastrointestinal disease or disorder;
- (ii) a joint disease or dysfunction;
- (iii) a skin disease or disorder;
- (iv) a uterine-related disorder;
- (v) heart-related condition;
- or
- (vi) Non-Alcoholic Fatty Liver Disease (NAFLD), chronic kidney disease (CDK), diabetes dyslipidemia, metabolic syndrome, hyperglycemia, or obesity,
- the method comprising administering a therapeutically effective amount of a pharmaceutical composition a subject in need thereof, wherein
- the pharmaceutical composition comprising:
- a cannabinoid acid ester compound of formula (I):
- wherein R1 and R2 are independently selected from C1-C10 alkyl, substituted C1-C10 alkyl, C2-C10 alkenyl, substituted C2-C10 alkenyl, C2-C10 alkynyl, and substituted C2-C10 alkynyl, or a pharmaceutically acceptable salt thereof;
- and
- a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.