Devices and methods related to colorimetric detection for dental uses
AssigneeCaviSense Inc.
InventorsGili NAVEH, Michael NATAN, Sabesh KANGALINGAM
Life of this patent
Estimating the term…
Abstract
The disclosure is directed to compositions and methods related to colorimetric detection for dental uses (e.g., detecting the presence or absence of a dental caries, and/or cavity or cavities, or precursor thereof), including a rapid unambiguous color indicator that allows for visualization by an unassisted eye based on a localized oral pH reading.
Claims180
A device for detection of a presence or absence of a dental caries, and/or cavity or cavities, and/or cavity activity risk, and/or caries risk, or precursor thereof, comprising:
- (a) a support, the support being configured for grasping;
- (b) a substrate attached to or layered upon the support and being suitable for absorption or containing a sensing agent and detection of the sensing agent without interference;
- and
- (c) a sensing agent, the sensing agent being suitable for providing a color change which is indicative of a pH value associated with the presence or absence of a dental caries, and/or cavity or cavities, risk for caries, caries activity, or precursor thereof.
A method of detecting a presence or absence of a dental caries, and/or cavity or cavities, or precursor thereof, comprising:
- (a) contacting a surface of a tooth with a sensing agent, or a support and/or substrate comprising the sensing agent, the sensing agent being configured to colorimetrically detect pH of saliva, plaque, or gingival crevicular fluid;
- and
- (b) determining a color change in the sensing agent, the color change being indicative of a pH value that is associated with the presence or absence of tooth demineralization, dental caries, caries risk, caries activity level, caries associated bacterial activity, and/or cavity or cavities, or precursor thereof, and/or risk of developing dental caries, and/or cavity or cavities presence or activity.
A method of detecting a response to a remineralization treatment of a dental caries, and/or cavity or cavities, in a subject, comprising:
- (a) contacting a surface of a tooth of the subject's with a sensing agent, or a support and/or substrate comprising the sensing agent, the sensing agent being configured to colorimetrically detect pH of saliva or gingival crevicular fluid;
- and
- (b) determining a color change in the sensing agent, the color change being indicative of a pH value that is associated with the presence or absence of a dental caries, and/or cavity or cavities, caries risk, caries activity level, and/or risk of developing dental caries, and/or cavity or cavities,
- wherein the lack of a pH value associated with the presence of a dental caries, and/or cavity or cavities, is indicative of a therapeutic response to a remineralization treatment.
A method of preparing an anthocyanin, a carotene, or a curcumin from a food and/or spice source, comprising (a) obtaining the food and/or spice source and (b) lyophilizing the food and/or spice source or an extract from the food and/or spice source into a powder.
Dependencies are inferred from the claim text.