Mouse model for retina degeneration and uses thereof
AssigneeChildren's Medical Center Corporation
InventorsYe Sun, Tianxi Wang
Life of this patent
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Abstract
Provided herein are irradiated mouse models which recapitulate the effects of ionizing radiation-induced microglia activation, eye injury and retinal degeneration, as well as methods for producing such mouse models. These mouse models are useful, for example, for the study of genes involved in the pathophysiology of retinal degeneration and for the development of methods for treating retinal degeneration in humans.
Claims31
An irradiated mouse which has been exposed to a dose of ionizing radiation, wherein the mouse comprises one or more retina exhibiting microglial activation, neovascularization, and/or photoreceptor degeneration.
A method for producing a mouse model of ionizing radiation-induced retinal degeneration, the method comprising administering to a mouse a dose of ionizing radiation, wherein the dose of ionizing radiation is sufficient to induce microglial activation, neovascularization, and/or photoreceptor degeneration in one or more retina of the mouse.
The method of any one of claims 15-19, wherein the administration results in increased growth of retinal blood vessels, as compared to the growth of retinal blood vessels before the administration.
Dependencies are inferred from the claim text.