Method for measuring concentration of per- and polyfluoroalkyl substance and liquid chromatography-tandem mass spectrometry system

Abstract

The present disclosure provides a method for measuring a concentration of a per- and polyfluoroalkyl substance and a liquid chromatography-tandem mass spectrometry system. The method includes: measuring concentrations of a plurality of per-and polyfluoroalkyl substances in a sample by liquid chromatography-tandem mass spectrometry in a primary measurement process of eluting the sample with an alkaline mobile phase, in which the plurality of per- and polyfluoroalkyl substances at least include one or more perfluoroalkyl phosphonic acids/phosphinic acids or polyfluoroalkyl phosphate esters. According to the method, by using the alkaline mobile phase to elute the sample, the rapid analysis on 93 PFASs including perfluoroalkyl phosphonic acids/phosphinic acids and polyfluoroalkyl phosphate esters can be completed by single injection. Additionally, the present disclosure also provides a method to rapidly analyze 10 PFASs by GC-MS/MS.

Dependencies are inferred from the claim text.