Therapeutic compounds and methods

A compound of formula (I):

• or a salt thereof, wherein:
• R1 is a 6-10 membered aryl, (C3-C6)cycloalkyl, or a 5-10 membered heteroaryl, which 6-10 membered aryl, (C3-C6)cycloalkyl, and 5-10 membered heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, nitro, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy;
• X is N or CH;
• Y is N or CH;
• ring A is phenyl, 3-8 membered heterocyclic ring, or a 5-10 membered heteroaryl, which phenyl, 3-8 membered heterocyclic ring and 5-10 membered heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, nitro, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy;
• R2 is —C(═O)—NRaRb or a 5-membered heteroaryl ring that is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, nitro, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, NRcRd, and (C2-C6)alkanoyloxy;
• Ra is H or (C1-C6)alkyl;
• and Rb is H, (C1-C6)alkyl, (C3-C6)cycloalkyl, or (C3-C6)cycloalkyl(C1-C6)alkyl, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, and (C3-C6)cycloalkyl(C1-C6)alkyl is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, carboxy, nitro, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, aryl, 5-10 membered heteroaryl, NReRf, and (C2-C6)alkanoyloxy;
• or
• Ra and Rb together with the nitrogen to which they are attached form a 3-8 membered heterocyclic ring that is optionally substituted with one or more groups independently selected from the group consisting of halo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy;
• each Rc and Rd is independently selected from the group consisting of H, (C1-C6)alkyl, (C3-C6)cycloalkyl, and (C3-C6)cycloalkyl(C1-C6)alkyl, or Rc and Rd together with the nitrogen to which they are attached form a 3-8 membered heterocyclic ring that is optionally substituted with one or more groups independently selected from the group consisting of halo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy;
• and
• each Re and Rf is independently selected from the group consisting of H, (C1-C6)alkyl, (C3-C6)cycloalkyl, and (C3-C6)cycloalkyl(C1-C6)alkyl, wherein (C1-C6)alkyl, (C3-C6)cycloalkyl, and (C3-C6)cycloalkyl(C1-C6)alkyl are optionally substituted with one or more halo, or Re and Rf together with the nitrogen to which they are attached form a 3-8 membered heterocyclic ring that is optionally substituted with one or more groups independently selected from the group consisting of halo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, and (C2-C6)alkanoyloxy.