Sensor integrated dressings and systems

A wound dressing comprising:

• a flexible substrate with a first, wound-facing side supporting a plurality of electronic components and a plurality of electronic connections and a second side opposite the first side;
• a non-stretchable coating applied to at least one of one or more electronic components of the plurality of electronic components or one or more electronic connections of the plurality of electronic connections and not to at least some regions of the first side of the substrate that do not include electronic components;
• a stretchable coating applied to the first side of the substrate including the at least some regions of the first side of the substrate that do not include electronic components, the stretchable coating applied directly over the non-stretchable coating;
• and
• a protective layer applied to the first side of the substrate, the protective layer configured to be removed to expose the first side of the substrate.

A method of manufacturing a wound dressing comprising:

• coating a first side of a flexible substrate with a first coating, the substrate comprising a second side opposite the first side, the first side of the substrate supporting a plurality of electronic components, wherein the first coating is applied to at least one of one or more electronic components of the plurality of electronic components and not to at least some regions of the first side of the substrate that do not include electronic components;
• coating the first side of the substrate with a second coating including the at least some regions of the first side of the substrate that do not include electronic components, wherein the second coating is applied over the first coating;
• adhering a wound contact layer to the first side and in contact with the second coating, the wound contact layer configured to contact a wound;
• then perforating the wound contact layer and the substrate coated with the first and second coating to create a plurality of through holes through the wound contact layer and the substrate coated with the first and second coating, the plurality of through holes configured to facilitate passage of fluid through the wound contact layer and the substrate.