Improving adoptive cell transfer therapy (act) treatment
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsMichael BERGER, Amijai Oriel SARAGOVI
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Abstract
Cells comprising a heterologous nucleic acid sequence that encodes for a trehalase enzyme and optionally a heterologous nucleic acid sequence that encodes for a trehalose transporter protein are provided. Pharmaceutical compositions comprising the cells, methods of adoptive cell transfer comprising administering the cells and methods of determining suitability of a subject for the performance of the methods are also provided. A pharmaceutical composition comprising pharmaceutical grade trehalose is also provided, as is a kit comprising both compositions of the invention.
Claims30
A mammalian immune cell comprising a heterologous nucleic acid sequence that encodes for a trehalase enzyme and a heterologous nucleic acid sequence that encodes a trehalose transporter protein.
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Dependencies are inferred from the claim text.