Extracellular Carboxylesterase 2 (CES2) for the Treatment of Metabolic Disease
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsJonathan Z. Long, Wei Wei
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Abstract
Methods of treating a metabolic disorder in a subject are provided. Aspects of the method include enhancing extracellular Carboxylesterase 2 (CES2) activity in the subject in order to treat the subject for the metabolic disorder. Also provided are compositions for use in practicing the methods.
Claims26
A method of treating a metabolic disorder in a subject, the method comprising enhancing extracellular CES2 activity in the subject in order to treat the subject for the metabolic disorder, wherein the extracellular CES2 activity is enhanced by administering a CES2 polypeptide lacking a C-terminal ER localization domain.
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An extracellular CES2 activity enhancing CES2 active agent comprising a CES2 polypeptide lacking a C-terminal ER localization domain.
A method of increasing exercise performance in a subject, the method comprising enhancing extracellular CES2 activity in the subject in order to increase exercise performance in the subject.
The method of claim 34, wherein the extracellular CES2 activity is enhanced by administering a CES2 active agent to the subject.
Dependencies are inferred from the claim text.