Cycloalkyl carboxylic acid derivatives as inhibitors of glycogen synthase 1 (gys1) and methods of use thereof

A compound of formula (I):

• or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein:
• m is 0, or 1, and nis 0, 1, or 2, wherein m+n is an integer from 1 to 2;
• Y1 and Y2 are each CH, or
• one of Y1 and Y2 is N and the other of Y1 and Y2 is CH;
• X1 and X2 are each independently H or halo;
• X3 is H, C1-6alkyl, or C3-10cycloalkyl, wherein the C3-10cycloalkyl of X3 is optionally substituted with one or more C1-6alkyl;
• Q1 is:
• (i) C6-10cycloalkyl, wherein the C6-10cycloalkyl of Q1 is optionally substituted with one or more C1-6alkyl,
• (ii) C6-20aryl, wherein the C6-20aryl of Q1 is optionally substituted with one or more Rb, wherein each Rb is independently C1-6alkyl, —C1-6alkoxy, —NH—C(O)—NH2, —NH—C(O)-(3-15 membered heterocyclyl), or 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Rb is optionally substituted with one or more C1-6alkyl,
• (iii) 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Q1 is optionally substituted with one or more oxo or C1-6alkyl, or
• (iv) 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Q1 is optionally substituted with one or more —NH2, and wherein the 5-20 membered heteroaryl of Q1 contains at least 1 annular N when m is 1,
• provided that, when X3 is H, then Q1 is C6-10cycloalkyl, wherein the C6-10cycloalkyl of Q1 is optionally substituted with one or more C1-6alkyl;
• and
• Ra is H, halo, —OH, or —NH—C(O)—C1-6alkoxy.