Implantable Device for Sustained Release of a Macromolecular Drug Compound

A polymer composition for use in a drug delivery device comprising from about 50 wt. % to about 99.5 wt. % of a polymer matrix that contains an ethylene vinyl acetate copolymer and from about 1 wt. % to about 50 wt. % of a plurality of water-soluble particles distributed within the polymer matrix, wherein the ethylene vinyl acetate copolymer has a vinyl acetate monomer content of from about 25 wt. % to about 50 wt. %, a melt flow index of from about 10 to about 80 grams per 10 minutes as determined in accordance with ASTM D1238-20 at a temperature of 190° C. and a load of 2.16 kilograms, and/or a melting temperature of from about 60° C. to about 120° C. as determined in accordance with ASTM D3418-15, and further wherein the water-soluble particles have a D50 particle size of about 150 micrometers or less and contain a non-polymeric, hydroxy-functional compound, wherein the hydroxy-functional compound includes a saccharide or a derivative thereof, wherein the composition further comprises a radio contrast agent.