Polypeptide sequencing reagents and methods of use
AssigneeQuantum-Si Incorporated
InventorBrian Reed
Life of this patent
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Abstract
Provided herein are novel amino acid binding proteins that recognize aspartate and/or glutamate in protein sequencing reactions; novel amino acid binding proteins that recognize arginine in protein sequencing reactions; and novel amino acid binding proteins that recognize glycine, alanine, and/or serine in protein sequencing reactions.
Claims32
1-32. (canceled)
A recombinant amino acid binding protein comprising an amino acid sequence that is at least 80% identical to SEQ ID NO:
- 1 (PS1259), wherein the amino acid sequence comprises amino acid substitutions at positions corresponding to S22, C23, and S25 of SEQ ID NO:
- 1.
34-36. (canceled)
(canceled)
40-42. (canceled)
48-66. (canceled)
A recombinant amino acid binding protein comprising an amino acid sequence that is at least 80% identical to SEQ ID NO:
- 1 (PS1259), wherein the amino acid sequence comprises a glutamine residue at a position corresponding to S25 of SEQ ID NO:
- 1.
68-69. (canceled)
73-75. (canceled)
(canceled)
80-82. (canceled)
A recombinant amino acid binding protein comprising an amino acid sequence that is at least 80% identical to SEQ ID NO:
- 2 (PS1122), wherein the amino acid sequence comprises amino acid substitutions at positions corresponding to T53 and one or more selected from K26, D32, L47, F59, and T75 of SEQ ID NO:
- 2.
84-94. (canceled)
96-141. (canceled)
Dependencies are inferred from the claim text.