Methylation for monitoring circannual rhythms
AssigneeUniversity of South Carolina
InventorsHippokratis Kiaris, Kim Tuyen Huynh Dam
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Abstract
Methods for monitoring circannual rhythms and/or determining birth period by detecting DNA methylation and oligonucleotide arrays therefor.
Claims20
A method comprising determining a methylation level of any one or more CpG sites in each of 10 or more genomic regions of a genome of a subject, wherein the genomic regions have sequences of any 10 or more of SEQ ID NOS:1-377 or sequences at least 80% identical thereto.
An array of immobilized oligonucleotides, wherein the oligonucleotides are configured to bind to amplicons of bisulfite modified genomic DNA, wherein the amplicons comprise bisulfite modified CpG sites corresponding to any one or more CpG sites in each of 10 or more genomic regions of a genome of a subject, wherein the genomic regions have sequences of any 10 or more of SEQ ID NOS:1-377 or sequences at least 80% identical thereto.
Dependencies are inferred from the claim text.