Enzyme based compositions and methods for removing dental calculi
AssigneePontis Biologics, Inc.
InventorDennis C. Mynarcik
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Abstract
Disclosed are compositions and formulations for removing dental calculus which comprise enzymes or other biocatalysts which cleave (i) surface-accessible nucleic acid polymers and (ii) glycoprotein carbohydrate chains at galactose residues. Optionally, one or more proteolytic enzymes are included. The compositions destroy the structural integrity of the calculus, allowing it to be readily removed without requiring special treatment by a trained dental professional. Also disclosed are methods for removing dental calculus using the disclosed compositions and formulations.
Claims25
A dental composition comprising:
- a. a DNase and/or RNase;
- b. chymotrypsin or a functional variant or derivative thereof;
- and
- c. an orally acceptable additive, carrier or excipient or any combination thereof.
A method for reducing or removing calculus dentalis in a subject in need thereof, the method comprising contacting a tooth surface with an effective amount of a composition comprising:
- a. DNAse I or a functional variant or derivatives thereof, and
- b. chymotrypsin or a functional variant or derivative thereof.
Dependencies are inferred from the claim text.