Highly soluble formulations of harmine

A method for masking the bitterness of a compound,

• wherein the compound is harmine or a pharmaceutically acceptable salt thereof, or DMT or a pharmaceutically acceptable salt thereof, the method comprising loading a compound having a bitter taste onto a carrier particle wherein
• a) the carrier particle comprises a loading cavity and wherein the carrier particle comprises a basic salt;
• and
• b) wherein the bitterness of the compound is masked by the carrier particle during oral mucosal absorption.

A pharmaceutical composition comprising carrier particles, comprising:

• a) a carrier particle comprising a loading cavity and comprising of a basic salt;
• and
• b) a compound having a bitter taste, wherein the compound is harmine or a pharmaceutically acceptable salt thereof, or DMT or a pharmaceutically acceptable salt thereof,
• wherein the bitterness of the compound is masked by the carrier particle during oral mucosal absorption.