Methods and compositions for treating sleep apnea
AssigneeThe Brigham and Women S Hospital, Inc.
InventorsD. Andrew Wellman, Luigi Taranto-Montemurro
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Abstract
Methods and compositions for the treatment of conditions associated with pharyngeal airway muscle collapse while the subject is in a non-fully conscious state, e.g., sleep apnea and snoring, comprising administration of a norepinephrine reuptake inhibitor (NRI) and a muscarinic receptor antagonist.
Claims7
1-46. (canceled)
A method of treating obstructive sleep apnea in a subject in need thereof, the method comprising administering to the subject an effective amount of atomoxetine and oxybutynin.
A method of treating obstructive sleep apnea in a subject in need thereof, the method comprising decreasing an apnea-hypopnea index (AHI) of the subject by generating a circulating concentration of atomoxetine and oxybutynin in the subject that results in a decrease in AHI.
A method of treating obstructive sleep apnea in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising:
- a first active ingredient, a second active ingredient, and one or more pharmaceutically acceptable excipients;
- wherein the first active ingredient comprises atomoxetine and the second active ingredient comprises oxybutynin.
Dependencies are inferred from the claim text.