Anti-freeze solutions for visual indicators of biospecimen time-temperature exposure
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorChad BORGES
Life of this patent
Estimating the term…
Abstract
An indicator system comprising permanganate, an organic reducing agent, an acid, and an inorganic perchlorate salt is provided herein. Methods for using the indicator system to monitor the integrity of a biospecimen are also provided. The systems and methods herein may provide easy-to-use, individual aliquot-level thawed-state indicators for indicating biospecimen time-temperature exposure.
Claims21
An indicator system comprising permanganate, an organic reducing agent, an acid, an aqueous solvent, and an inorganic perchlorate salt initially configured to prevent reduction of the permanganate to Mn2+,
- wherein a mixture of the permanganate, the organic reducing agent, the acid, the aqueous solvent, and the inorganic perchlorate salt is an eutectic composition having a predetermined freezing point, and
- wherein at temperature above the predetermined freezing point the organic reducing agent causes a reduction reaction of permanganate to Mn2+ and at temperature below the predetermined freezing point the reduction reaction is stopped.
11-13. (canceled)
Dependencies are inferred from the claim text.