Method for estimating cause of prolongation of blood clotting time, and information processing device

An information processing device communicable with an automatic analyzer configured to acquire a clot waveform showing a change in light amount over time according to a coagulation reaction of a reaction liquid generated by mixing a test sample composed of plasma separated from blood acquired from a subject and a reagent, the information processing device comprising:

• a computer system including a processor and a memory,
• wherein the computer system is configured to execute:
• acquiring the clot waveform from the automatic analyzer;
• acquiring a first waveform by performing before-after differentiation processing on the clot waveform;
• acquiring a first fitted waveform by performing fitting processing on the clot waveform,
• acquiring a second fitted waveform by performing fitting processing on the first waveform;
• acquiring a third waveform by performing before-after differentiation processing on the second fitted waveform;
• acquiring a first normalized waveform, a second normalized waveform, and a third normalized waveform by normalizing the first fitted waveform, the second fitted waveform, and the third waveform, respectively, on a light amount axis and a time axis;
• extracting a feature from each of the first normalized waveform, the second normalized waveform, and the third normalized waveform;
• and
• estimating a cause of prolongation of a blood clotting time for the test sample based on a known feature extracted from a sample group for which a cause of prolongation of a blood clotting time is known and the feature extracted from each of the first normalized waveform, the second normalized waveform, and the third normalized waveform.

A method for estimating a cause of prolongation of a blood clotting time for a test sample from a clot waveform showing a change in light amount over time according to a coagulation reaction of a reaction liquid generated by mixing the test sample composed of plasma separated from blood acquired from a subject and a reagent, the method comprising:

• aligning data lengths of clot waveform data on a time axis;
• estimating a plurality of causes of prolongation of blood clotting times by applying the clot waveform data, of which the data lengths are aligned, to a neural network;
• and
• presenting a cause of prolongation of a blood clotting time for the test sample based on probabilities belonging to the estimated causes of prolongation of the blood clotting times.

A method for estimating a cause of prolongation of a blood clotting time, the method comprising:

• preparing a series of samples by mixing plasma separated from blood acquired from a subject and normal plasma at a plurality of mixing ratios;
• acquiring a series of clot waveforms showing changes in light amount over time according to coagulation reactions of reaction liquids generated by mixing the series of samples and a reagent;
• acquiring a series of first waveforms by performing before-after differentiation processing on the series of clot waveforms, respectively;
• acquiring a series of first fitted waveforms by performing fitting processing on the series of clot waveforms, respectively;
• acquiring a series of second fitted waveforms by performing fitting processing on the series of first waveforms, respectively;
• acquiring a series of third waveforms by performing before-after differentiation processing on the series of second fitted waveforms, respectively;
• acquiring a series of first normalized waveforms, a series of second normalized waveforms, and a series of third normalized waveforms by normalizing the series of first fitted waveforms, the series of second fitted waveforms, and the series of third waveforms, respectively, on a light amount axis and a time axis;
• extracting features from at least one of the series of first normalized waveforms, the series of second normalized waveforms, the series of third normalized waveforms, or a series of waveform data obtained by performing a nonlinear operation thereon;
• and
• estimating a cause of prolongation of a blood clotting time for the sample using at least one of the series of features extracted from the series of clot waveforms.

An information processing device communicable with an automatic analyzer configured to prepare a series of samples by mixing plasma separated from blood acquired from a subject and normal plasma at a plurality of mixing ratios, and acquire a series of clot waveforms showing changes in light amount over time according to coagulation reactions of reaction liquids generated by mixing the series of samples and a reagent, the information processing device comprising:

• a computer system including a processor and a memory,
• wherein the computer system is configured to execute:
• acquiring the series of clot waveforms from the automatic analyzer;
• acquiring a series of first waveforms by performing before-after differentiation processing on the series of clot waveforms, respectively;
• acquiring a series of first fitted waveforms by performing fitting processing on the series of clot waveforms, respectively;
• acquiring a series of second fitted waveforms by performing fitting processing on the series of first waveforms, respectively;
• acquiring a series of third waveforms by performing before-after differentiation processing on the series of second fitted waveforms, respectively;
• acquiring a series of first normalized waveforms, a series of second normalized waveforms, and a series of third normalized waveforms by normalizing the series of first fitted waveforms, the series of second fitted waveforms, and the series of third waveforms, respectively, on a light amount axis and a time axis;
• extracting features from at least one of the series of first normalized waveforms, the series of second normalized waveforms, the series of third normalized waveforms, or a series of waveform data obtained by performing a nonlinear operation thereon;
• and
• estimating a cause of prolongation of a blood clotting time for the sample using at least one of the series of features extracted from the series of clot waveforms.