Method for producing 4-(aminomethyl)cyclohexane-1-carboxylic acid
AssigneesKirin Holdings Kabushiki Kaisha, Kyowa Hakko Bio Co., Ltd.
InventorsAsuka GODA, Makoto YAMASHITA, Kento KOKETSU, Yuriko AOKI YAMAMOTO, Taro WATANABE
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Abstract
A production method according to one embodiment is a method for producing 4-(aminomethyl)cyclohexane-1-carboxylic acid from 1,4-bis(aminomethyl)cyclohexane using a protein consisting of an amino acid sequence having 60% or more identity to an amino acid sequence shown in any one of SEQ ID NOs. 1 to 4 and 103 to 105 and having transamination activity, and a protein consisting of an amino acid sequence having 50% or more identity to an amino acid sequence shown in any one of SEQ ID NOs. 19 to 22, 35 to 46 and 127 to 139 and having aldehyde dehydrogenase activity.
Claims11
-9. (canceled)
The method according to claim 32, wherein said method further comprises
- producing 4-(aminomethyl)cyclohexane-1-carbaldehyde from 1,4-bis(aminomethyl)cyclohexane in the presence of an aminotransferase.
-31. (canceled)
A method for producing cis- and/or trans-4-(aminomethyl)cyclohexane-1-carboxylic acid, comprising producing cis- and/or trans-4-(aminomethyl)cyclohexane-1-carboxylic acid from cis- and/or trans-4-(aminomethyl)cyclohexane-1-carbaldehyde in the presence of an aldehyde dehydrogenase.
Dependencies are inferred from the claim text.