US 2026/0000744 A1 · TOLEROGENIC COMPOSITION

Tolerogenic composition

OwnerSilvia Rodriguez Vidal, MíRiam Salvadó Molero +11inventors

InventorsSILVIA RODRIGUEZ VIDAL, MÍRIAM SALVADÓ MOLERO, MONTSERRAT MANCERA ARTEU, SILVIA RODRÍGUEZ FERNÁNDEZ, LIDIA ALMENARA FUENTES, ESTELA ROSELL MASES, BRUNA BARNEDA ZAHONERO, MARTI DALMASES ARNELLA, BERNABÉ ZEA CHECA, MARTA VIVES PI, CARMEN ESPEJO RUIZ, HERENA EIXARCH AHUFINGER, JUAN VERDAGUER AUTONELL

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Abstract

Tolerogenic liposome-based compositions and uses thereof for treating immune disorders. The compositions include two populations of liposomes. The first population of liposomes has a size in the range from 2 to 200 nm, and the second population of liposomes has a size in the range from 500 to 2000 nm. The liposomes of the first and second populations carry one or more antigens. The liposomal membrane of each liposome in the first and second liposome populations include phosphatidylserine in an amount ranging from 20 to 60% by weight with respect to the total composition of the liposome's membrane.

Claims17

Dependent claims

A composition comprising two populations of liposomes, wherein:

the first population of liposomes has a size in the range from 2 to 200 nm,
the second population of liposomes has a size in the range from 500 to 2000 nm,
the liposomes of the first and second populations carry one or more antigens, and
the liposomal membrane of each liposome in the first and second liposome populations comprises phosphatidylserine in an amount ranging from 20 to 60% by weight with respect to the total composition of the liposome's membrane.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

19/132,226Filed 22 Nov 2023

Priority

EP 22383126.423 Nov 2022

Published

1 Jan 2026

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Classification18 codes

A61K 39/001
Vertebrate antigens: preparations to induce tolerance to non-self, e.g. prior to transplantation
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/127
Dispersions; Emulsions: synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 9/1271
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant: non-conventional liposomes,…