Synergistic Herbal Compositions for Pain Management and Opioid Use Reduction

A method for reducing pain and opioid use in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition comprising:

• a) 0.5-2.5 grams of a first Mitragyna speciosa powder selected from the group consisting of Red Borneo Kratom, Green Maeng Da Kratom, Red Bali Kratom, and Green Malay Kratom;
• b) 0.5-2.5 grams of a second Mitragyna speciosa powder selected from the group consisting of Red Borneo Kratom, Green Maeng Da Kratom, Red Bali Kratom, and Green Malay Kratom, wherein the second Mitragyna speciosa powder is different from the first Mitragyna speciosa powder;
• c) 0.5-2.5 grams of a Piper methysticum from a Vanuatu strain;
• d) 0.5-2.5 grams of a Curcuma longa extract comprising 50-95% curcuminoids;
• e) 0.1-1.0 grams of a Scutellaria baicalensis extract comprising 30-90% baicalin;
• f) 5-50 milligrams of a Piper nigrum extract comprising 85-99% piperine;
• g) 10-100 milligrams of a Cannabis sativa extract comprising 90-99.9% cannabidiol (CBD);
• h) 100-600 milligrams of L-theanine;
• i) 100-500 milligrams of a Sophora japonica extract comprising 85-99% quercetin;
• and
• optionally j) 100-1000 milligrams of 4-amino-3-phenylbutanoic acid (phenibut) and 100-1000 milligrams of a Valeriana officinalis extract;
• wherein the ratio of components a):b):c):d):e):f):g):h):i) is 1:1:1:1:0.2-0.8:0.01-0.1:0.02-0.2:0.2-1.2:0.2-1 by weight;
• and wherein administration of the composition results in at least a 30-60% reduction in pain as measured by a visual analog scale and enables a reduction or elimination of opioid use by the subject.

A pharmaceutical composition for treating pain and reducing opioid use comprising one or more selected from

• a) 0.5 to 2.5 grams of Red Borneo Kratom or Red Bali Kratom;
• b) 0.5 to 2.5 grams of Green Maeng Da Kratom or Green Malay Kratom;
• c) 0.5 to 2.5 grams of Kava root from the Vanuatu strain;
• d) 0.5 to 2.5 grams of Curcumin or a Curcumin extract;
• e) 0.1 to 1.0 grams of Baicalin or a Baicalin extract;
• f) 5 to 25 milligrams of Piperine or a Piperine extract;
• g) 10 to 100 milligrams of Cannabidiol (CBD) or a CBD extract;
• h) 100 to 800 milligrams of L-Theanine;
• and
• i) 100 to 600 milligrams of Quercetin or a Quercetin extract;
• wherein the Red Borneo Kratom and Green Maeng Da Kratom are included for daytime pain relief and alertness;
• the Red Bali Kratom and Green Malay Kratom are included for nighttime pain relief and sleep induction;
• and the composition is formulated for oral administration in an amount effective to reduce pain and opioid use in a subject in need thereof.