Compounds, compositions, and methods for reducing production of trimethylamine
AssigneeThe Cleveland Clinic Foundation
InventorsStanley L. Hazen, James T. Anderson
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Abstract
Provided herein are substituted quaternary amine salt compounds and compositions thereof for inhibiting production of trimethylamine (TMA), as well as inhibiting the conversion of choline to trimethylamine, and such compounds, and compositions thereof, utilized for treating for example, kidney disease, diabetes and cardiovascular disease, disorders that are associated with inhibiting the conversion of choline to trimethylamine.
Claims26
A polyol compound, or a pharmaceutically acceptable salt thereof, wherein at least one hydroxy group of the polyol compound is functionalized with a moiety of formula (I):
- wherein:
- R1 is halomethyl or C3-C6 cycloalkyl;
- L is a linker;
- and
- X− is an anion selected from a halide and a carboxylate.
Dependencies are inferred from the claim text.