Pharmaceutical composition that inhibits production of hepatitis b virus protein, pharmaceutical composition for treating hepatitis b, and screening method
AssigneeFUJIFILM Corporation
InventorsRyota HABA, Kazuki SHIMANE, Nozomi YAMASHITA
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Abstract
An object of the present invention is to provide a pharmaceutical composition useful as a novel anti-hepatitis B virus agent and a screening method. According to the present invention, there is provided a pharmaceutical composition that inhibits the production of a hepatitis B virus protein, in which the pharmaceutical composition inhibits the expression or the function of a protein belonging to the YTHDC family.
Claims19
A pharmaceutical composition that inhibits a production of a hepatitis B virus protein,
- wherein the pharmaceutical composition inhibits an expression or a function of a protein belonging to a YTHDC family.
A pharmaceutical composition for treating hepatitis B in a subject, the pharmaceutical composition comprising an inhibitor to an expression or a function of a protein belonging to a YTHDC family.
A method of screening a substance that inhibits a production of a hepatitis B virus protein, the method comprising:
- (a) a step of bringing cells infected with hepatitis B virus or cells expressing hepatitis B virus into contact with a test substance that reduces an expression level of a protein belonging to a YTHDC family or with a test substance that inhibits a function or an activity of the protein;
- (b) a step of measuring an ability of producing a hepatitis B virus protein in the cells infected with hepatitis B virus or the cells expressing hepatitis B virus;
- and
- (c) a step of selecting a substance having an activity of inhibiting a production of the hepatitis B virus protein of the step (b).
A method for inhibiting a production of a hepatitis B virus protein, which comprises administering a pharmaceutical composition which inhibits an expression or a function of a protein belonging to a YTHDC family, to a subject.
A method for treating hepatitis B in a subject, which comprises administering a pharmaceutical composition comprising an inhibitor to an expression or a function of a protein belonging to a YTHDC family, to a subject.
Dependencies are inferred from the claim text.