Antibacterial compounds, method of production and use thereof

Abstract

The present invention discloses an antibacterial compound of Formula 1 or pharmaceutically acceptable salt thereof: wherein X is CH, S, CH—NH2; R1 is C1-C8 alkyl, substituted alkyl, alkyl amine, substituted amine; preferably R1 is methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, methyl amine, ethylamine, propylamine, isopropyl amine, isobutylamine, N-ethylprop-2-yn-1-amine, N-isopropyl propane-1,3-diamine, N1-isopropyl ethane-1,3-diamine, 1-butyl-2-methylguanidine, N1-ethyl-N1-propylethane-1,2-diamine, cyclobutyamine, phosphate, sulphate; R2 is hydrogen, alkyl, substituted alkyl; preferably R2 is methyl, propyl, isopropyl; R3 is hydrogen, alkyl, substituted alkyl; and preferably R3 is methyl, propyl, isopropyl. The Formula 1 or pharmaceutically acceptable salt thereof is an imidazole glycerol phosphate dehydratase (IGPD) inhibitor and treats or prevents or ameliorates tuberculosis.

Dependencies are inferred from the claim text.