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US 2025/0381237 A1Published application
Oncolytic virus expressing a car t cell target and uses thereof
AssigneeCity of Hope
InventorsYuman Fong, Saul J. Priceman, Stephen J. Forman, Nanhai Chen, Anthony K. Park
Life of this patent
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Abstract
An oncolytic poxvirus encoding a truncated human CD19 is used in conjunction with a chimeric antigen receptor to treat solid tumors.
Claims16
A recombinant oncolytic virus comprising a nucleotide sequence encoding a truncated human CD19 lacking a functional signaling domain and comprising amino acids 22-323 of SEQ ID NO:29, wherein the nucleotide sequence encoding the truncate truncated CD19 is operably linked to a promoter.
-18. (canceled)
Dependencies are inferred from the claim text.