Prodrug kit for multi-pronged chemotherapy

Prodrug comprising a chemotherapeutic compound radical Ct, a linear or branched self-immolative linker L and one, two, three, four or more initiators (F1, F2, F3, F4), wherein

• L is covalently bound to a nitrogen, amine or oxygen radical of Ct;
• L comprises one, two, three, four or more amine radicals;
• each of initiators (F1, F2, F3, F4) is covalently bound to an amine radical of L;
• each of initiators (F1, F2, F3, F4) is configured for enzymatic cleavage from L by fibroblast activation protein (FAP);
• L is configured for release of Ct upon cleavage of any one of initiators (F1, F2, F3, F4);
• initiators (F1, F2, F3, F4) independently of one another comprise or have a structure selected from the group of structures comprising
• wherein the terminal carbonyl is covalently bound to an amine radical of the self-immolative linker L, X=—H or —CH3, Y=—H or —F, —R1 is a radical of a first pharmaco-kinetic modulating moiety and Z is a moiety having a structure selected from the group comprising structures (1), (2), (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14), (15), (16), (17), (18), (19), (20), (21), (22), (23), (24) and (25) with
• and
• Ct is a radical of a chemotherapeutic compound selected from the group comprising 1,2,3,4-Tetrahydrogen-staurosporine, 17-Dmag, 2-Aminopropanenitrile, 4SC202, ABBV-CLS-484, Abemaciclib, Abexinostat, Acalabrutinib, Acetylbufalin, Aderbasib, Afatinib, Afuresertib, Alectinib, Alisertib, Alpelisib, Alvocidib, AMD3465, Anlotinib, Apalutamide, AR-42, Asciminib, Atuveciclib, Avapritinib, Axitinib, AZD7762, BAY1125976, Belinostat, β-Hydroxyisovaleric acid, BF211, Bicalutamide, Binimetinib, Bortezomib, Bosutinib, Brigatinib, Bufalin, Buparlisib, Buthionine sulfoximine, Cabozantinib, Capivasertib, Capmatinib, Carfilzomib, CEP-9722, Ceralasertib, Ceritinib, Chidamide, CHR-3996, Citarinostat, Cobimetinib, CompK, Copanlisib, Crenolanib, Crizotinib, CUDC-101, Dabrafenib, Daclatasvir, Dacomitinib, Darolutamide, Dasatinib, Dasatinib D1, Dasatinib D2, Dasatinib D3, Dasatinib D4, Decitabine, Defactinib, Degarelix, Diethylstilbestrol, Dinaciclib, Dp44mT, DpC, DUPA, Duvelisib, E7016, Ebvaciclib, Eganelisib, Elimusertib, Emavusertib, Enasidenib, Encorafenib, Enitociclib, Entinostat, Entrectinib, Enzalutamide, Epacadostat, Epigallocatechin gallate, Epoxomicin, Erdafitinib, Erismodegib, Erlotinib, Everolimus, Fasudil, Fedratinib, Filgotinib, Foslinanib, Fostamatinib, Fruquintinib, Galunisertib, Ganetespib, Gedatolisib, Gefitinib, GFH018, Gilteritinib, Givinostat, Glasdegib, Goserelin, GSK2256098, GSK269962A, GSK690693, GUL, Halofuginone, Hymecromone, Ibrutinib, Icotinib, Idelalisib, Imatinib, Imiquimod, Infigratinib, Iniparib, Ipatasertib, Itacitinib, Ivaltinostat, Ivosidenib, Ixazomib, Kevetrin, Lapatinib, Larotrectinib, Lenalidomide, Leniolisib, Lenvatinib, Leuprolide, Linsitinib, Lonafarnib, Lorlatinib, Losartan, Lucitanib, Luminespib, M1096, Marizomib, ME-344, Merestinib, Metformin, MG132, Midostaurin, Miransertib, Mivavotinib, MK2206, MMP-9 Inhibitor I, Mobocertinib, Mocetinostat, Motesanib, MRTX1133, Navitoclax, Nazartinib, Nedisertib, Neratinib, Nilotinib, Nilutamide, Nintedanib, Niraparib, NMS-P118, NMS-P515, NSC668394, NSC95397, Numidargistat, NVP-2, Olaparib, Olmutinib, Omipalisib, Oprozomib, Osimertinib, OTS-964, Palbociclib, Pamiparib, Panobinostat, Paricalcitol, Parsaclisib, Pazopanib, Pemetrexed, Pemigatinib, Pevonedistat, Pexidartinib, Pifusertib, Plerixafor, PMPA, Ponatinib, Practinostat, Pralsetinib, Prednisone, Prexasertib, Prinomastat, Propranolol, Quisinostat, Quizartinib, Ralimetinib, Ravoxertinib, Regorafenib, Relugolix, Resminostat, Resveratrol, Retaspimycin, Retinoic acid, Ribociclib, Ricolinostat, Rigosertib, Ripretinib, RO-3306, Rocilinostat, Rogaratinib, Romidepsin, Rucaparib, Ruxolitinib, S2, S5, Saridegib, SBI-0654454, SCH772984, Seliciclib, Selitrectinib, Selpercatinib, Selumetinib, SGN-2FF, SGX393, Shikonin, Silibinin, Sitravatinib, Sonidegib, Sorafenib, Sotorasib, Staurosporine, SU11274, Sunitinib, Surufatinib, Tacedinaline, Tadalafil, Talazoparib, Taletrectinib, Tarloxotinib, Taselisib, Tazemetostat, Tefinostat, Temsirolimus, Tetrazole, Tivozanib, Tofacitinib, Tozasertib, Trametinib, Tranilast, Tretinoin, Trichostatin, Tucatinib, Tucidinostat, Tuvusertib, Ubenimex, Umbralisib, Uprosertib, USL311, Vactosertib, Valproic acid, Valsartan, Vandetanib, Veliparib, Vemurafenib, Venetoclax, Verteporfin, Vismodegib, Vorinostat, WRG-28, WZ811, Xevinapant, Zandelisib, Zanubrutinib, ZM447439, Abiraterone, Aclarubicin, Adozelesin, Alrestatin, Amanitin, Amrubicin, Anthramycin, Arenastatin, Bizelesin, Bleomycin, Camptothecin, Capecitabine, Carzelesin, CC-1065, Chaconine, Chlorambucil, Cryptophycin-24, Cyclophosphamide, Cytarabine, Dacarbazine, Dactinomycin, Daunorubicin, DAVLBH, Deruxtecan, Dexamethasone, Dichloro acetic acid, Dimethyl-SGD-1882, Docetaxel, Dolastatin-10, Doxorubicin, Duocarmycin A, Duocarmycin B1, Duocarmycin B2, Duocarmycin C1, Duocarmycin C2, Duocarmycin D, Duocarmycin GA, Duocarmycin SA, Emetine, Epirubicin, Eribulin, Etoposide, Floxuridine, Fludarabine, Fluorouracil, Flutamide, Fulvestrant, Gemcitabine, Idarubicin, Ifosfamide, Irinotecan, L-Asparaginase, Lomustine, Melphalan, Mertansine, Methotrexate, Milataxel, Mitoxantrone, Monomethyl Auristatin E, Maytansine, Maytansinoid, Ozogamicin, Paclitaxel, Pirarubicin, Pixantrone, Podophyllotoxin, Procarbazine, Rapamycin, Rachelmycin, Salinomycin, SB-T-1214, Selinexor, SN-38, Solamargine, Solanine, Talirine, Temozolomide, Tesetaxel, SG3199 (Tesirine), Thapsigargin, Tomatine, Topotecan, Tubulysin B, Valrubicin, Vinblastine, Vincristine, Vinorelbine, VIP126, Zorubicin.