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US 2025/0375724 A1Published application
Filter system usable as cell culture clarification filter in protein purification
AssigneeSartorius Stedim Biotech GmbH
InventorsCeren Gencoglu, Martin Leuthold, Prisca Baptista
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Abstract
The present invention relates to a filter system, which can be used as a clarification filter/depth filter for cell culture clarification before chromatography and/or ultrafiltration for protein purification, as well as to a method of separating cells and other contaminants from a fluid containing one or more target components by employing the filter system of the present invention.
Claims13
A filter system comprising, in this order,
- a first synthetic non-woven layer having a first average pore size A;
- a second synthetic non-woven layer having a second average pore size B;
- a third synthetic non-woven layer having a third average pore size C;
- a fourth synthetic non-woven layer having a fourth average pore size D;
- and
- a membrane layer having a fifth average pore size E,
- wherein the first average pore size A is from 15.0 pm to 50.0 pm, the second average pore size B is from 7.50 pm to 30.0 pm, the third average pore size C is from 5.00 pm to 15.0 pm, the fourth average pore size D is from 3.00 pm to 10.0 pm, the fifth average pore size E is from 0.010 pm to 2.5 pm, and A>B>C>D>E.
4 more elements
Dependencies are inferred from the claim text.