Sorbent manifold for a dialysis system

A method comprising:

• pumping a dialysate from a dialyzer outlet, through a dialysate flow path to a first inlet of a sorbent manifold system,
• wherein the sorbent manifold system comprises:
• the first inlet and a first outlet in a sorbent manifold;
• the sorbent manifold comprising a plurality of passageways fluidly connectable to the first inlet and first outlet and to a sorbent dialysis system;
• one or more valves and one or more sensors in the sorbent manifold,
• wherein the one or more sensors in the sorbent manifold is located between the first inlet of the sorbent manifold and the one or more valves;
• a controller controlling the one or more valves to direct fluid to bypass a sorbent cartridge based on measurements of the one or more sensors;
• and
• pumping the dialysate through a first passageway and second passageway of the plurality of passageways to the first outlet of the sorbent manifold;
• pumping the dialysate from the first outlet of the sorbent manifold to an inlet of the sorbent cartridge;
• pumping the dialysate from an outlet of the sorbent cartridge to the second inlet of the sorbent manifold;
• and
• pumping the dialysate from the second inlet to the second outlet of the sorbent manifold and into the dialysate flow path downstream of the sorbent cartridge.