Functionalized polyurethane and meniscus prosthesis, the preparation method thereof and the uses therefor
AssigneeWest China Hospital, Sichuan University
InventorsWeili FU, Xia JIANG, Yi ZHOU
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AssigneeWest China Hospital, Sichuan University
InventorsWeili FU, Xia JIANG, Yi ZHOU
Estimating the term…
A functionalized polyurethane, meniscus prosthesis, the preparation method thereof, and the uses therefor are disclosed. The meniscus prosthesis is manufactured by using polyurethane as the base material and incorporating a self-healing chemical bond, the dynamic dimethylglyoxime-urethane group. Additionally, hyaluronic acid coated with adamantane structures is introduced onto the surface of the self-healing polyurethane elastomer, creating a supramolecular lubricating coating with stress response characteristics. This successfully mimics the dynamic self-healing ability and physiological cyclic lubrication mechanism of natural meniscus, offering a novel solution for the treatment of meniscus injuries and holding great potential value in clinical applications.
A functionalized polyurethane, characterized in that it comprises a self-healing polyurethane elastomer and an adamantane-hyaluronic acid composite, wherein the adamantane-hyaluronic acid composite is coated on the surface of the self-healing polyurethane elastomer, and the thickness of the adamantane-hyaluronic acid composite is 10-20 μm;
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