Use of the extracellular matrix to formulate a flexible lung bioadhesive
AssigneeTransfertech Ssh S.E.C.
InventorsPatrick VERMETTE, Laurine GALLIEN, Marco SIROIS, Vignesh DHANDAPANI, Vickie RINGUETTE
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Abstract
It is provided a bioadhesive comprising an isolated extracellular matrix (ECM) from a decellularized organ with preserved (ultra) structure comprising laminins, collagen 4, collagen-6, collagen-1, fibronectin, elastin, fibrillin, ECM protein 1, proteoglycans, glycoproteins, biglycan, histidine rich glycoprotein, tenascin, and heparan sulfate proteoglycan 2. The bioadhesive described herein and provided composition can be used to seal intra-operative pulmonary air leaks after lung surgery.
Claims23
An isolated extracellular matrix (ECM) from a decellularized organ comprising laminins, collagen 4, collagen-6, collagen-1, fibronectin, elastin, fibrillin, ECM protein 1, proteoglycans, glycoproteins, biglycan, histidine rich glycoprotein, tenascin, and heparan sulfate proteoglycan 2.
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Dependencies are inferred from the claim text.