Compositions and methods for modifying bile acids to regulate lipid and steroid metabolism
AssigneeThe Regents of the University of California
InventorsJonathan Lynch, Elaine Hsiao, Erika L. Gonzalez, Kayli Choy
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Abstract
Provided herein are methods and compositions related to treating or preventing metabolic disorder.
Claims24
A method of preventing or treating a metabolic disorder in a subject, comprising administering to the subject a composition comprising a bacterial strain that expresses a bile salt-regulating gene or bile acid-regulating gene.
17-22. (canceled)
A method of treating or preventing a metabolic disorder in a subject, comprising
- (a) depleting the gut microbiota of the subject,
- (b) administering a composition comprising a bacterial strain that expresses a bile salt-regulating gene or bile acid-regulating gene.
24-37. (canceled)
A bacterial strain comprising a bile salt-regulating gene or bile acid-regulating gene, wherein the bacterial strain expresses a bile salt-regulating gene or bile acid-regulating gene encoded by an exogenous nucleic acid.
40-53. (canceled)
(canceled)
Dependencies are inferred from the claim text.