Selective tolerization - methods of selectively generating tolerogenic dendritic cells

A method to selectively produce tolerogenic dendritic cells, the method comprising the following steps:

• a) Providing dendritic cells from a recipient;
• b) Exposing the dendritic cells of step a) to an apoptotic agent;
• c) Providing physiologic dendritic cells from the recipient;
• and
• d) Combining the apoptotic dendritic cells of step b) with the physiologic dendritic cells of step c).

A method to selectively produce tolerogenic dendritic cells, the method comprising the following steps:

• a) Providing a first sample of dendritic cells obtained from a subject;
• b) Exposing the dendritic cells of step a) to an apoptotic agent;
• c) Providing a second sample of dendritic cells obtained from the subject;
• and
• d) Combining the apoptotic dendritic cells of step b) with the dendritic cells of step c).

A composition comprising:

• (a) a sample of dendritic cells obtained from a subject;
• (b) an apoptotic agent;
• and
• (c) an autoantigen or a fragment thereof.