# US 2025/0375412 A1 · Urolithin gummy (pectin) formulations

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- Number: US 2025/0375412 A1
- Document ID: US20250375412A1
- Status: Published application
- Kind: A1
- Application number: 19/311,629
- Filed: 2025-08-27
- Published: 2025-12-11
- Earliest claimed: 2023-06-01
- Assignees: Amazentis SA
- Applicants: Amazentis SA
- Inventors: Christopher L. Rinsch; Anurag Singh; William Blanco-Bose; Davide D'Amico; Alan McClure
- Web page: https://patentgrep.com/patent/US20250375412A1

## CPC

- A23L 29/231: Pectin; Derivatives thereof
- A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)}
- A23G 3/36: characterised by the composition {containing organic or inorganic compounds}
- A23G 3/42: characterised by the carbohydrates used, e.g. polysaccharides (containing dairy products A23G3/46)
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/1652: {Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623)}
- A61K 31/37: Coumarins, e.g. psoralen
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/46: Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23G: COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF

## Abstract

The invention relates to composition of urolithins comprising urolithins and pectin and formulations of urolithins, specifically chewable formulations, comprising urolithins and a gelling agent. The invention further comprises compositions and chewable formulations comprising urolithins in combination with other active ingredients and processes for the preparation of such compositions and formulations. The invention further comprises methods of using such compositions and formulations in the treatment of conditions and diseases and for the promotion of health and performance, such in the improving muscle function.

## Claims

### Claim 1

A composition, comprising urolithin A or a salt thereof; and pectin.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the pectin is selected from low methoxyl pectin, high methoxyl pectin, and amidated low methoxyl pectin, or a mixture of any of them.

### Claim 3 (depends on 2)

The composition of claim 2, wherein the pectin is an amidated low methoxyl pectin.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the amount of urolithin A or salt thereof is about 1% to about 20% (w/w).

### Claim 5 (depends on 4)

The composition of claim 4, wherein the amount of urolithin A or salt thereof is about 5% to about 15% (w/w).

### Claim 6 (depends on 4)

The composition of claim 4, wherein the amount of urolithin A or salt thereof is about 5% to about 10% (w/w).

### Claim 7 (depends on 1)

The composition of claim 1, wherein the amount of pectin is about 0.5% to about 4% (w/w).

### Claim 8 (depends on 7)

The composition of claim 7, wherein the amount of pectin is about 0.5% to about 3% (w/w).

### Claim 9 (depends on 1)

The composition of claim 1, wherein the ratio of urolithin A to pectin is about 1:2 (w/w) to about 10:1 (w/w).

### Claim 10 (depends on 1)

The composition of claim 1, further comprising one or more low-calorie sweeteners.

### Claim 11 (depends on 10)

The composition of claim 10, wherein the one or more low-calorie sweeteners is selected from stevia and fructooligosaccharide.

### Claim 12 (depends on 1)

The composition of claim 1, further comprising soluble fibre.

### Claim 13 (depends on 12)

The composition of claim 12, wherein the soluble fibre is soluble tapioca fibre.

### Claim 14 (depends on 1)

The composition of claim 1, further comprising a citrate salt.

### Claim 15 (depends on 14)

The composition of claim 14, wherein the citrate salt is sodium citrate.

### Claim 16 (depends on 1)

The composition of claim 1, further comprising one or more low-calorie sweeteners; soluble fibre; and a citrate salt.

### Claim 17 (depends on 16)

The composition of claim 16, wherein the amount of urolithin A or salt thereof is about 1% to about 20% (w/w).

### Claim 18 (depends on 17)

The composition of claim 17, wherein the amount of pectin is about 0.5% to about 4% (w/w).

### Claim 19 (depends on 18)

The composition of claim 18, wherein the amount of one or more low-calorie sweetener is about 25% to about 45% (w/w); the amount of soluble fibre is about 25% to about 45% (w/w); and the amount of citrate salt is about 0.1% to about 2% (w/w).

### Claim 20 (depends on 19)

The composition of claim 19, wherein the pectin is selected from low methoxyl pectin, high methoxyl pectin, and amidated low methoxyl pectin, or a mixture of any of them.

### Claim 21 (depends on 20)

The composition of claim 20, wherein the pectin is amidated low methoxyl pectin extracted from citrus peel.

### Claim 22 (depends on 19)

The composition of claim 19, wherein the soluble fibre is soluble tapioca fibre.

### Claim 23 (depends on 19)

The composition of claim 19, wherein the one or more low-calorie sweeteners is selected from stevia and fructooligosaccharide.

### Claim 24 (depends on 19)

The composition of claim 19, wherein the citrate salt is sodium citrate.

### Claim 25 (depends on 1)

The composition of claim 1, wherein the composition is in the form of a gummy.

### Claim 26 (depends on 1)

The composition of claim 1, wherein the amount of urolithin A or salt thereof is about 100 mg to about 2500 mg.

### Claim 27 (depends on 1)

The composition of claim 1, wherein the amount of urolithin A or salt thereof is about 1000 mg.

### Claim 28 (depends on 1)

The composition of claim 1, wherein the amount of urolithin A or salt thereof is about 500 mg.

### Claim 29 (depends on 1)

The composition of claim 1, wherein the amount of urolithin A or salt thereof is about 250 mg.
