# US 2025/0375375 A1 · Antimicrobial gels

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- Number: US 2025/0375375 A1
- Document ID: US20250375375A1
- Status: Published application
- Kind: A1
- Application number: 18/876,675
- Filed: 2023-06-23
- Published: 2025-12-11
- Earliest claimed: 2022-06-24
- Applicants: Royal Melbourne Institute of Technology
- Inventors: Saffron BRYANT; Aaron ELBOURNE; Sumeet WALIA; Miyah AWAD; Gary BRYANT; Tamar GREAVES
- Web page: https://patentgrep.com/patent/US20250375375A1

## CPC

- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A01N 25/04: Dispersions, {emulsions, suspoemulsions, suspension concentrates} or gels (foams A01N25/16)
- A01N 25/34: Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
- A01P 1/00: Disinfectants; Antimicrobial compounds or mixtures thereof
- A01P 3/00: Fungicides
- A61F 13/00063: {comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic (drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00)}
- A61K 9/7007: {Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence)}
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/242: Gold; Compounds thereof
- A61K 33/243: Platinum; Compounds thereof
- A61K 33/30: Zinc; Compounds thereof
- A61K 33/34: Copper; Compounds thereof
- A61K 33/38: Silver; Compounds thereof
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/18: Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K 47/186: {Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide}
- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61L 15/60: Liquid-swellable gel-forming materials, e.g. super-absorbents
- A61L 26/0066: {Medicaments; Biocides}
- A61L 26/008: {Hydrogels or hydrocolloids}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

The present disclosure relates generally to antimicrobial gels. In particular, the present disclosure relates to an antimicrobial gel comprising a eutectic solvent and a gelling agent which can be used as a drug delivery vehicle for antimicrobial agents, including for the topical delivery of antimicrobial agents to the skin of a subject. The present disclosure also relates to processes for preparing the antimicrobial gel, and to methods, uses and compositions comprising the antimicrobial gel.

## Claims

### Claim 1

An antimicrobial gel, comprising:
a) a eutectic solvent comprising a mixture of at least one hydrogen bond acceptor and at least one hydrogen bond donor;
b) a gelling agent; and
c) an antimicrobial agent.

### Claim 2 (depends on 1)

The antimicrobial gel of claim 1, wherein the concentration of antimicrobial agent (mg/g) is between about 0.001 to about 100 based on the total weight of the antimicrobial gel.

### Claim 3 (depends on 1, 2)

The antimicrobial gel of claim 1 or claim 2, wherein the antimicrobial agent is a topical antimicrobial agent.

### Claim 4 (depends on 1, 2, 3)

The antimicrobial gel of any one of claims 1 to 3, wherein the antimicrobial agent is selected from the group consisting of antimicrobial nanoparticles, an antibiotic, an antifungal, an antibacterial, an antiparasitic, and an antiviral, or a combination thereof.

### Claim 5 (depends on 4)

The antimicrobial gel of claim 4, wherein the antimicrobial nanoparticles are metallic nanoparticles, preferably selected from the group consisting of silver, gold, nickel, platinum, palladium, cadmium, zinc, and copper nanoparticles, and combinations thereof, more preferably silver nanoparticles.

### Claim 6 (depends on 1, 2, 3, 4, 5)

The antimicrobial gel of any one of claims 1 to 5, wherein the hydrogen bond acceptor is selected from the group consisting of a quaternary ammonium compound, a quaternary phosphonium compound, a quaternary sulfonium compound, a metal salt, an alcohol, and an amino acid, or combinations thereof.

### Claim 7 (depends on 1, 2, 3, 4, 5, 6)

The antimicrobial gel of any one of claims 1 to 6, wherein the hydrogen bond donor is selected from the group consisting of a sugar, a polyol, a carboxylic acid, and a carbamide, or combinations thereof.

### Claim 8 (depends on 1, 2, 3, 4, 5, 6, 7)

The antimicrobial gel of any one of claims 1 to 7, wherein eutectic solvent comprises a mixture selected from choline chloride and glycerol, choline chloride and urea, or betaine and glycerol.

### Claim 9 (depends on 1, 2, 3, 4, 5, 6, 7, 8)

The antimicrobial gel of any one of claims 1 to 8, wherein the eutectic solvent is a deep eutectic solvent (DES), wherein the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor in the eutectic solvent is at or near the eutectic point of the solvent.

### Claim 10 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9)

The antimicrobial gel of any one of claims 1 to 9, wherein the concentration of eutectic solvent (% w/w) is between about 70 to about 99.9 based on the total weight of the antimicrobial gel.

### Claim 11 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10)

The antimicrobial gel of any one of claims 1 to 10, wherein the gelling agent is derived from one or more of of algae, plants, animals, fungi, or bacteria.

### Claim 12 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)

The antimicrobial gel of any one of claims 1 to 11, wherein the gelling agent comprises a polysaccharide.

### Claim 13 (depends on 12)

The antimicrobial gel of claim 12, wherein the polysaccharide is selected from the group consisting of cellulose, starch, carrageenan, agarose, agar, alginate, and gellan gum, or a derivative thereof.

### Claim 14 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)

The antimicrobial gel of any one of claims 1 to 13, wherein the gelling agent is a cellulose or derivative thereof, preferably bacterial cellulose.

### Claim 15 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)

The antimicrobial gel of any one of claims 1 to 14, wherein the concentration of gelling agent (% w/w) is between about 0.1 to about 10 based on the total weight of the antimicrobial gel.

### Claim 16 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)

The antimicrobial gel of any one of claims 1 to 15, comprising:
a) the eutectic solvent in an amount of between about 80% w/w to about 99.9% w/w;
b) the gelling agent in an amount of between about 0.1% w/w to about 5% w/w; and
c) the antimicrobial agent in an amount of between about 0.0001% w/w to about 1% w/w, based on the total weight of the antimicrobial gel.

### Claim 17 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)

The antimicrobial gel of any one of claims 1 to 16, wherein the antimicrobial gel has a water content (% w/w) of less than about 5 based on the total weight of the antimicrobial gel.

### Claim 18 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)

The antimicrobial gel of any one of claims 1 to 17, for use in treating and/or preventing a skin condition.

### Claim 19 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)

A process for preparing an antimicrobial gel of any one of claims 1 to 18, comprising mixing a gelling agent and a eutectic solvent under conditions effective to form a gel, and wherein the process comprises mixing an antimicrobial agent with the eutectic solvent and gelling agent or contacting the gel with the antimicrobial agent under conditions effective to incorporate the antimicrobial agent into the gel.

### Claim 20 (depends on 19)

The process of claim 19, further comprising incorporating the antimicrobial gel on or within a topical dressing.

### Claim 21 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)

A topical dressing comprising an antimicrobial gel of any one of claims 1 to 20.

### Claim 22 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 21)

A method of treating and/or preventing a skin condition in a subject in need thereof, the method comprising applying a therapeutically effective amount of an antimicrobial gel of any one of claims 1 to 18, or a topical dressing of claim 21 to the skin of the subject.

### Claim 23 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 21)

Use of an antimicrobial gel of any one of claims 1 to 18, or a topical dressing of claim 21 for the manufacture of a medicament for treating and/or preventing a skin condition in a subject.

### Claim 24 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 21)

Use of an antimicrobial gel of any one of any one of claims 1 to 18, or a topical dressing of claim 21 for treating and/or preventing a skin condition responsive to an antimicrobial agent.