# US 2025/0375280 A1 · Interdental papilla reconstruction method using hyaluronic acid

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- Number: US 2025/0375280 A1
- Document ID: US20250375280A1
- Status: Published application
- Kind: A1
- Application number: 19/188,035
- Filed: 2025-04-24
- Published: 2025-12-11
- Earliest claimed: 2024-06-05
- Assignees: Novabio Co., Ltd.
- Applicants: Novabio Co., Ltd.
- Inventors: Hyun Bae SEO; Min Jun BAE; Dong geun HAN
- Web page: https://patentgrep.com/patent/US20250375280A1

## CPC

- A61C 19/063: {Medicament applicators for teeth or gums, e.g. treatment with fluorides}
- A61L 27/20: Polysaccharides
- A61K 31/728: Hyaluronic acid
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/52: Hydrogels or hydrocolloids
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 2300/236: Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
- A61L 2400/06: Flowable or injectable implant compositions
- A61L 2430/34: for soft tissue reconstruction
- A61C: DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE (non-driven toothbrushes A46B; {tongue scrapers A61B17/24;} preparations for dentistry A61K6/00; preparations for cleaning the teeth or mouth A61K8/00, A61Q11/00)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The disclosure relates to an interdental papilla reconstruction method using hyaluronic acid. One aspect of the disclosure, the interdental papilla reconstruction method, can conveniently reconstruct the lost or receded interdental papilla compared to conventional treatment methods. In addition, according to an aspect of the disclosure, the interdental papilla reconstruction method, the interdental papilla can be effectively reconstructed without pain or side effects. Further, the interdental papilla reconstruction method of the disclosure is highly useful as a rescue treatment for quickly resolving unexpected gingival recession or interdental papilla loss occurring during dental treatments.

## Claims

### Claim 1

An interdental papilla reconstruction method, comprising:
an administration step of administering a composition including hyaluronic acid or a pharmaceutically acceptable salt thereof to gingiva,
wherein the composition comprises a composition with a complex viscosity of 250 to 850 Pa·s.

### Claim 2 (depends on 1)

The interdental papilla reconstruction method of claim 1, wherein the administration step comprises administering the composition in an amount of 0.005 to 0.05 cc.

### Claim 3 (depends on 1)

The interdental papilla reconstruction method of claim 1, wherein the administration step comprises administering the composition 1 to 10 administrations, in an amount of 0.001 to 0.01 cc per administration.

### Claim 4 (depends on 1)

The interdental papilla reconstruction method of claim 1, wherein the administration step comprises administering the composition to the gingiva with an area of 0.1 to 4 mm2.

### Claim 5 (depends on 1)

The interdental papilla reconstruction method of claim 1, wherein the composition includes a gel formulation.

### Claim 6 (depends on 1)

The interdental papilla reconstruction method of claim 1, wherein the method has an interdental papilla reconstruction rate expressed by Equation 1 below of 70% or more:
Interdental papilla reconstruction rate (%)=100×Black triangle area after composition administration/black triangle area before composition administration. [Equation 1]

### Claim 7 (depends on 1)

The interdental papilla reconstruction method of claim 1, wherein the composition is administered using a needle of 25 to 35G.

### Claim 8 (depends on 1)

The interdental papilla reconstruction method of claim 1, wherein the administration step comprises administering the composition to a lower 1 to 3 mm site of an apex of the interdental papilla.

### Claim 9 (depends on 1)

The interdental papilla reconstruction method of claim 1, further comprising: a molding step.

### Claim 10 (depends on 1)

The interdental papilla reconstruction method of claim 1, wherein the method is performed at intervals of 2 to 4 weeks.

### Claim 11 (depends on 1)

An interdental papilla reconstruction kit, comprising:
a composition including hyaluronic acid or a pharmaceutically acceptable salt thereof; and
a treatment manual describing the interdental papilla reconstruction method according to claim 1.