Therapeutic and/or prophylactic anti-viral agent
AssigneeCentre for Cellular and Molecular Platforms
InventorsParesh Brijalal PATEL, Taslimarif SAIYED, Balachandran RAVINDRAN
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Abstract
A recombinant heat shock protein (hsp70) or domains thereof is derived from filarial worm Setaria digitata or Homo sapiens so as to provide therapeutic and prophylactic anti-viral agents against respiratory viral infections. In that respect, a method of preparation of the recombinant heat shock protein (hsp70) is used. And the recombinant heat shock protein (hsp70) or domains thereof may be used for treatment and/or prophylaxis of one or more symptoms of respiratory viral infections in a subject.
Claims22
A recombinant heat shock protein (hsp70) or domains thereof derived from filarial worm Setaria digitata or Homo sapiens for treating or preventing a disease or disorder associated with respiratory viral infections wherein the recombinant hsp70 protein is of SEQ. ID NO. 1 or SEQ. ID NO. 2 or a variant thereof.
A method of preparing recombinant hsp70 protein or domains thereof comprising the following steps:
- preparing a DNA construct comprising nucleotide sequence encoding one or more of recombinant hsp70 protein or domains thereof derived from filarial worm Setaria digitata or Homo sapiens;
- constructing a bacterial expression vector comprising the DNA construct;
- transforming a suitable prokaryotic host cell by said vector to obtain a transformed hostcell;
- culturing said transformed host cell in a culture medium to express transformed gene of recombinant hsp70 protein or domains thereof;
- subjecting the culture medium to suitable physical disruption technique followed by purifying expressed recombinant hsp70 protein or domains thereof.
A method of treatment, medicinal, curative, therapy and/or prophylaxis of disease or disorder associated with respiratory viral infections, the method comprising administering to a subject in need thereof, a physiologically effective amount of at least one of recombinant hsp70 protein or domains thereof derived from filarial worm Setaria digitata or Homo sapiens or a formulation or composition thereof.
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Dependencies are inferred from the claim text.