Medical hydrogel containing ultrasonically-imageable bubble microspheres and preparation method thereof
AssigneeShanghai Reunion Medical Co., Ltd.
InventorsYali WANG, Churong WANG, Zhanpeng ZHANG, Zhen PAN
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Abstract
Provided are a medical hydrogel containing ultrasonically-imageable bubble microspheres and a preparation method thereof. The medical hydrogel containing the ultrasonically-imageable bubble microspheres is formed by in-situ crosslinking of a polyethylene glycol precursor solution and a poly-amino crosslinker solution containing bubble microspheres, the polyethylene glycol precursor solution consisting of a multi-arm polyethylene glycol derivative and a buffer solution A.
Claims20
A medical hydrogel containing ultrasonically-imageable bubble microspheres, wherein the medical hydrogel containing the ultrasonically-imageable bubble microspheres comprises bubble microspheres and a crosslinked product at surfaces of the bubble microspheres;
- and the crosslinked product is prepared by crosslinking a multi-arm polyethylene glycol derivative with a poly-amino crosslinker.
A medical hydrogel containing ultrasonically-imageable bubble microspheres, wherein the medical hydrogel containing the ultrasonically-imageable bubble microspheres is formed by in-situ crosslinking of a polyethylene glycol precursor solution and a poly-amino crosslinker solution containing bubble microspheres, the polyethylene glycol precursor solution comprising a multi-arm polyethylene glycol derivative and a buffer solution A;
- and
- the buffer solution A has a pH of 4 to 10.
Dependencies are inferred from the claim text.