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US 2025/0367273 A1Published application
Treatment of insect bite hypersensitivity
AssigneeUniversitäT ZüRich
InventorsAntonia FETTELSCHOSS, Martin BACHMANN
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Abstract
The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of insect bite hypersensitivity of equine mammals, preferably of horses. Furthermore, the invention provides methods for preventing or treating insect bite hypersensitivity of equine mammals, preferably of horses.
Claims20
A composition comprising:
- (a) a core particle with at least one first attachment site;
- and
- (b) at least one antigen with at least one second attachment site, wherein said at least one antigen is
- (i) an equine Interleukin-5 antigen (eIL-5 antigen), wherein said eIL-5 antigen comprises a protein with the amino sequence selected from SEQ ID NO:1 or a protein with an amino acid sequence of at least 90% amino acid sequence identity with SEQ ID NO:1;
- (ii) an equine Eotaxin antigen (eEotaxin antigen), wherein said eEotaxin antigen comprises a protein with the amino sequence selected from SEQ ID NO:6 or a protein with an amino acid sequence of at least 90%, amino acid sequence identity with SEQ ID NO:6;
- (iii) an equine Interleukin-31 antigen (eIL-31 antigen), wherein said eIL-31 antigen comprises a protein with the amino sequence selected from SEQ ID NO:12 or a protein with an amino acid sequence of at least 90% amino acid sequence identity with SEQ ID NO:12;
- wherein (a) and (b) are linked through said at least one first and said at least one second attachment site via at least one non-peptide covalent bond.
4 more elements
Dependencies are inferred from the claim text.