Kynurenine aminotransferase and products thereof for the treatment of arthritic diseases
AssigneesInstitut National de Recherche Pour L'Agriculture, L'Alimentation et L’Environnement, Institut National Des Sciences Et Industries Du Vivant Et De L'environnement, Sorbonne Universite, Assistance Publique-Hopitaux de Paris, Institut National de la Sante et de la Recherche Medicale, Centre National De La Recherche Scientifique, Universite De Lorraine, Universite Paris-Saclay
InventorsHARRY SOKOL, DAVID MOULIN, PHILIPPE LANGELLA, ANNE AUCOUTURIER, LUIS BERMUDEZ
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Abstract
The present invention relates to the treatment of an arthritic disease such as rheumatoid arthritis with a kynurenine aminotransferase, a living recombinant bacterium which has been genetically modified to express and secrete said kynurenine aminotransferase, and/or a product of said kynurenine aminotransferase which is xanthurenic acid, a derivative thereof, or any pharmaceutically acceptable salt or solvate thereof.
Claims16
1-17. (canceled)
A method of treating an arthritic disease comprising administering a composition to a subject in need of treatment, said composition comprising
- a kynurenine aminotransferase (KAT), and/or
- a living recombinant bacterium which has been genetically modified to express and secrete said kynurenine aminotransferase, and/or
- a product of said kynurenine aminotransferase which is xanthurenic acid, a derivative thereof, or any pharmaceutically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.